Annarita Fiorillo Selected Research

tryparedoxin

2/2020	Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
11/2018	Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
5/2015	Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.
1/2012	The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway.

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Annarita Fiorillo Research Topics

Disease

8	Neoplasms (Cancer) 04/2020 - 03/2010
7	Infections 06/2021 - 01/2012
6	Leishmaniasis 04/2020 - 01/2012
3	Huntington Disease (Huntington's Disease) 12/2021 - 01/2017
3	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 10/2020
2	Trypanosomiasis 04/2020 - 01/2018
1	Bacterial Infections (Bacterial Infection) 01/2018
1	Carcinoma (Carcinomatosis) 01/2018
1	Weight Loss (Weight Reduction) 01/2017
1	Neglected Diseases 01/2012

Drug/Important Bio-Agent (IBA)

5	EnzymesIBA 04/2020 - 01/2015
5	tryparedoxin peroxidaseIBA 02/2020 - 01/2012
4	trypanothione reductaseIBA 04/2020 - 01/2015
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2020 - 01/2015
4	tryparedoxinIBA 02/2020 - 01/2012
3	CalciumIBA 10/2020 - 11/2015
3	trypanothioneIBA 02/2020 - 01/2012
3	Calcium-Binding ProteinsIBA 01/2017 - 09/2014
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2020
2	Pharmaceutical PreparationsIBA 04/2020 - 11/2015
1	Huntingtin ProteinIBA 12/2021
1	Biological ProductsIBA 06/2021
1	Sigma-1 ReceptorIBA 01/2021
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 04/2020
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 04/2020
1	Adenosine Triphosphate (ATP)IBA 04/2020
1	Sulfides (Thioethers)IBA 02/2020
1	glycerate 1,3-biphosphateIBA 01/2018
1	Adenosine Diphosphate (ADP)IBA 01/2018
1	AntimonyIBA 01/2018
1	Arsenicals (Arsenic Compounds)IBA 01/2018
1	NucleotidesIBA 01/2018
1	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)IBA 01/2018
1	Coordination ComplexesIBA 01/2018
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	PENTAIBA 11/2015
1	ArginaseIBA 01/2015
1	theasinensin AIBA 01/2015
1	trypanothione synthetaseIBA 01/2015
1	deoxyhypusine synthaseIBA 01/2015
1	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2015
1	PolyaminesIBA 01/2015
1	Spermidine SynthaseIBA 01/2015
1	Adenosylmethionine DecarboxylaseIBA 01/2015
1	deoxyhypusine hydroxylaseIBA 01/2015
1	Sulfhydryl Compounds (Thiols)IBA 01/2012

Therapy/Procedure

2	Therapeutics 01/2018 - 03/2010